BDBM467604 (R)-N-(1-Acryloylpiperidin-3-yl)-4-oxo-5-phenyl-4,5-dihydro-3H-1- thia-3,5,8-triazaacenaphthylene-2-carboxamide;::US10800792, Example 257::US10822348, Example 257

SMILES C=CC(=O)N1CCC[C@H](C1)NC(=O)c1sc2nccc3n(-c4ccccc4)c(=O)[nH]c1c23

InChI Key InChIKey=JWSQOLWJHPFPNP-UHFFFAOYSA-N

Data  1 KI  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 467604   

TargetTyrosine-protein kinase BTK(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM467604(US10822348, Example 257 | (R)-N-(1-Acryloylpiperid...)
Affinity DataIC50: 398nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK [386-659](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM467604(US10822348, Example 257 | (R)-N-(1-Acryloylpiperid...)
Affinity DataIC50: 398nMAssay Description:A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2021
Entry Details
US Patent

TargetTyrosine-protein kinase BTK(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM467604(US10822348, Example 257 | (R)-N-(1-Acryloylpiperid...)
Affinity DataKi:  6.42E+3nMAssay Description:Covalent inhibition of recombinant human GST-tagged BTK (2 to 659 end residues) expressed in baculovirus expression system assessed as inhibition con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed