BDBM467457 N-(1-Acryloylazetidin-3-yl)-5-(2-methyl-4-phenoxyphenyl)-4-oxo- 4,5-dihydro-3H-1-thia-3,5,8-triazaacenaphthylene-2-carboxamide;::US10800792, Example 109::US10822348, Example 109

SMILES Cc1cc(Oc2ccccc2)ccc1-n1c2ccnc3sc(C(=O)NC4CN(C4)C(=O)C=C)c([nH]c1=O)c23

InChI Key InChIKey=KNBNTDHHCQJMQZ-UHFFFAOYSA-N

Data  1 KI  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 467457   

TargetTyrosine-protein kinase BTK [386-659](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM467457(US10822348, Example 109 | N-(1-Acryloylazetidin-3-...)
Affinity DataIC50: 63.1nMAssay Description:A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM467457(US10822348, Example 109 | N-(1-Acryloylazetidin-3-...)
Affinity DataIC50: 63.1nMAssay Description:TBDMore data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK [386-659](Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM467457(US10822348, Example 109 | N-(1-Acryloylazetidin-3-...)
Affinity DataIC50: 39.8nMAssay Description:A BTK kinase lanthascreen binding assay monitors compound binding to unphosphorylated-BTK kinase domain (UP-BTK), by competing with a fluorescent lab...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/21/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase BTK(Mouse)
Janssen Research & Development

Curated by ChEMBL
LigandPNGBDBM467457(US10822348, Example 109 | N-(1-Acryloylazetidin-3-...)
Affinity DataIC50: 130nMAssay Description:Inhibition of BTK in C57Bl/6 mouse splenocyte assessed as reduction in anti-IgM-induced CD69 expression incubated for 1 hr followed anti-IgM stimulat...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed
TargetTyrosine-protein kinase BTK(Human)
Janssen Pharmaceutica

US Patent
LigandPNGBDBM467457(US10822348, Example 109 | N-(1-Acryloylazetidin-3-...)
Affinity DataKi:  141nMAssay Description:Covalent inhibition of recombinant human GST-tagged BTK (2 to 659 end residues) expressed in baculovirus expression system assessed as inhibition con...More data for this Ligand-Target Pair
In Depth
Date in BDB:
8/20/2022
Entry Details Article
PubMed