BDBM466857 US10800767, Example 1::US10800767, Example 16

SMILES CC(C)c1cc(Oc2c(Cl)cc(NCc3noc(=O)[nH]3)cc2Cl)nn(C)c1=O

InChI Key InChIKey=RXOOADSEUCHRBT-UHFFFAOYSA-N

Data  4 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 466857   

TargetThyroid hormone receptor beta(Human)
Terns

US Patent
LigandPNGBDBM466857(US10800767, Example 16 | US10800767, Example 1)
Affinity DataEC50:  7.60nMAssay Description:LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen TR-FRET Thyroid Receptor beta Coactivator Assay kit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetThyroid hormone receptor beta(Human)
Terns

US Patent
LigandPNGBDBM466857(US10800767, Example 16 | US10800767, Example 1)
Affinity DataEC50:  44.2nMAssay Description:LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen TR-FRET Thyroid Receptor beta Coactivator Assay kit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetThyroid hormone receptor alpha(Human)
Terns

US Patent
LigandPNGBDBM466857(US10800767, Example 16 | US10800767, Example 1)
Affinity DataEC50:  49.5nMAssay Description:LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen TR-FRET Thyroid Receptor beta Coactivator Assay kit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent

TargetThyroid hormone receptor alpha(Human)
Terns

US Patent
LigandPNGBDBM466857(US10800767, Example 16 | US10800767, Example 1)
Affinity DataEC50:  82.4nMAssay Description:LanthaScreen TR-FRET Thyroid Receptor alpha Coactivator Assay kit (ThermoFisher) and LanthaScreen TR-FRET Thyroid Receptor beta Coactivator Assay kit...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
US Patent