BDBM466500 US10799605, Example 5::US20240287046, Compound C-2

SMILES COc1cccc(OC)c1-c1cc(nn1-c1ccc(cc1C(C)C)C(=O)N(C)CCCN(C)CCCN(C)C(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1)C(=O)NC1(C2CC3CC(C2)CC1C3)C(O)=O

InChI Key

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 466500   

TargetNeurotensin receptor type 1(Human)
3B Pharmaceuticals

US Patent
LigandPNGBDBM466500(US10799605, Example 5 | US20240287046, Compound C-...)
Affinity DataIC50: 20nMAssay Description:Ca2+ ions are usually kept at nanomolar levels in the cytosol of cells, and act in a number of signal transduction pathways as second messengers. Man...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
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TargetNeurotensin receptor type 1(Human)
3B Pharmaceuticals

US Patent
LigandPNGBDBM466500(US10799605, Example 5 | US20240287046, Compound C-...)
Affinity DataIC50: 2.90nMAssay Description:In order to determine the binding affinity of compounds comprising a radiolabel for NTR1, a radioligand binding assay was carried out. A radioligand ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/1/2021
Entry Details
Go to US Patent

TargetNeurotensin receptor type 1(Human)
3B Pharmaceuticals

US Patent
LigandPNGBDBM466500(US10799605, Example 5 | US20240287046, Compound C-...)
Affinity DataIC50: 4.46nMAssay Description:The binding affinities of test compounds were determined by a radioligand competitive binding assay using 177Lu labeled C-1 as the reference radiolig...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/12/2024
Entry Details
Go to US Patent