BDBM466306 (R)—N-benzyl-1-(6-cyclopropyl[1,3]thiazolo[4,5-b]pyrazin-2-yl)pyrrolidine-2-carboxamide::US10793582, Example 192

SMILES O=C(NCc1ccccc1)[C@H]1CCCN1c1nc2ncc(nc2s1)C1CC1

InChI Key InChIKey=GSOXASRTWPSMKL-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 466306   

TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Human)
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM466306((R)—N-benzyl-1-(6-cyclopropyl[1,3]thiazolo[4,...)
Affinity DataIC50: 33nMAssay Description:To a reaction mixture (45 μL) containing 3.0 μmol/L kynurenine, 10 μmol/L pyridoxal phosphate, 2.0 ng/μL human recombinant KAT-II...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
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