BDBM466295 (R)—N-benzyl-1-[7-ethyl-6-(1-methyl-1H-pyrazol-4-yl)[1,3]thiazolo[4,5-b]pyridin-2-yl]pyrrolidine-2-carboxamide::US10793582, Example 170

SMILES CCc1c(cnc2nc(sc12)N1CCC[C@@H]1C(=O)NCc1ccccc1)-c1cnn(C)c1

InChI Key InChIKey=HJDAIKLEXWVBIQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 466295   

TargetKynurenine/alpha-aminoadipate aminotransferase, mitochondrial(Human)
Mitsubishi Tanabe Pharma

US Patent
LigandPNGBDBM466295((R)—N-benzyl-1-[7-ethyl-6-(1-methyl-1H-pyrazo...)
Affinity DataIC50: 34nMAssay Description:To a reaction mixture (45 μL) containing 3.0 μmol/L kynurenine, 10 μmol/L pyridoxal phosphate, 2.0 ng/μL human recombinant KAT-II...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
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