BDBM464643 CIS-1-(Cyclopropyl-methyl)-8-dimethylamino-3-[2-methyl-2-(2-oxo-pyrrolidin-1- yl)-propyl]-8-phenyl-1,3-diazaspiro[4.5]decan-2-one::US10793556, Example SC_4072::US10793556, Example SC_4073::US10793556, Example SC_4074::US10793556, Example SC_4075::US10793556, Example SC_4076

SMILES CN(C)[C@]1(CC[C@]2(CN(CCC3(O)CCS(=O)(=O)CC3)C(=O)N2CC2CCC2)CC1)c1ccccc1

InChI Key InChIKey=QHKULTIHQVUDJD-UHFFFAOYSA-N

Data  10 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 464643   

TargetNociceptin receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM464643(US10793556, Example SC_4072 | US10793556, Example ...)
Affinity DataKi:  1nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
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TargetNociceptin receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM464643(US10793556, Example SC_4072 | US10793556, Example ...)
Affinity DataKi:  6nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
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TargetNociceptin receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM464643(US10793556, Example SC_4072 | US10793556, Example ...)
Affinity DataKi:  10nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
Go to US Patent

TargetNociceptin receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM464643(US10793556, Example SC_4072 | US10793556, Example ...)
Affinity DataKi:  12nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
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TargetMu-type opioid receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM464643(US10793556, Example SC_4072 | US10793556, Example ...)
Affinity DataKi:  17nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM464643(US10793556, Example SC_4072 | US10793556, Example ...)
Affinity DataKi:  39nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
Go to US Patent

TargetNociceptin receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM464643(US10793556, Example SC_4072 | US10793556, Example ...)
Affinity DataKi:  235nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl. 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM464643(US10793556, Example SC_4072 | US10793556, Example ...)
Affinity DataKi:  255nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM464643(US10793556, Example SC_4072 | US10793556, Example ...)
Affinity DataKi:  300nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Human)
Gruenenthal

US Patent
LigandPNGBDBM464643(US10793556, Example SC_4072 | US10793556, Example ...)
Affinity DataKi:  460nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
Go to US Patent