BDBM464558 US10793549, Compound G-42

SMILES Cc1cc(Cl)c(CNC(=O)c2cc(cc3n(cc(Cl)c23)S(=O)(=O)C2(CC=C)CC2)-c2ccc(nc2)-n2ccn(CC(C)(F)F)cc2)c(=O)[nH]1

InChI Key InChIKey=QOYBYCVGYWVUIM-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 464558   

TargetHistone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM464558(US10793549, Compound G-42)
Affinity DataIC50: 21nMAssay Description:Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
Go to US Patent