BDBM464555 US10793549, Compound G-40

SMILES CC(C)n1ccn(cc1)-c1ncc(cn1)-c1cc(C(=O)NCc2c(Cl)cc(C)[nH]c2=O)c2c(Cl)cn(c2c1)S(=O)(=O)C1(CC=C)CC1

InChI Key InChIKey=FDGNPMJCDIJXOQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 464555   

TargetHistone-lysine N-methyltransferase EZH2 [Y641F]/Polycomb protein EED/Polycomb protein SUZ12(Human)
Shanghai Haiyan Pharmaceutical Technology

US Patent
LigandPNGBDBM464555(US10793549, Compound G-40)
Affinity DataIC50: 15nMAssay Description:Recombinant PRC2 (EZH2-Y641F) was purchased from Active motif company, S-adenosyl-methionine (SAM) and Poly-L-lysine (PLL) were purchased from Sigma-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2021
Entry Details
Go to US Patent