BDBM464227 US10787450, Example 107::methyl 3-(6-ethyl-5- (1H-pyrazol-4- yl)pyridin-2-yl)-1-(3- fluoro-5- methoxybenzyl)-2- oxo-1,3,8- triazaspiro[4.5]decane- 8-carboxylate

SMILES CCc1nc(ccc1-c1cn[nH]c1)N1CC2(CCN(CC2)C(=O)OC)N(Cc2cc(F)cc(OC)c2)C1=O

InChI Key InChIKey=CLNMZHVOEVRWEU-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 464227   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM464227(methyl 3-(6-ethyl-5- (1H-pyrazol-4- yl)pyridin-2-y...)
Affinity DataIC50: 3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2021
Entry Details
US Patent