BDBM464209 8-acetyl-3-(6-ethyl-5-(1H-pyrazol-4- yl)pyridin-2-yl)-1-(3-fluoro-5- methoxybenzyl)-1,3,8- triazaspiro[4.5]decan-2-one::US10787450, Example 89

SMILES CCc1nc(ccc1-c1cn[nH]c1)N1CC2(CCN(CC2)C(C)=O)N(Cc2cc(F)cc(OC)c2)C1=O

InChI Key InChIKey=ILRQTKGEZMXESB-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 464209   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM464209(8-acetyl-3-(6-ethyl-5-(1H-pyrazol-4- yl)pyridin-2-...)
Affinity DataIC50: 3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2021
Entry Details
US Patent