BDBM464204 3-(5-(1H-pyrazol-4-yl)pyridin-2-yl)-8- acetyl-1-(3-methoxybenzyl)-1,3,8- triazaspiro[4.5]decan-2-one::US10787450, Example 84

SMILES COc1cccc(CN2C(=O)N(CC22CCN(CC2)C(C)=O)c2ccc(cn2)-c2cn[nH]c2)c1

InChI Key InChIKey=PLXDQRUDJAMWRQ-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 464204   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM464204(3-(5-(1H-pyrazol-4-yl)pyridin-2-yl)-8- acetyl-1-(3...)
Affinity DataIC50: 3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2021
Entry Details
US Patent