BDBM464181 3-(4-(1H-pyrazol-4-yl)phenyl)- 1-(4-fluoro-3-methoxybenzyl)- 1,3,8-triazaspiro[4.5]decan-2- one::US10787450, Example 59

SMILES COc1cc(CN2C(=O)N(CC22CCNCC2)c2ccc(cc2)-c2cn[nH]c2)ccc1F

InChI Key InChIKey=DSAHCXTVRZTVQG-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 464181   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM464181(3-(4-(1H-pyrazol-4-yl)phenyl)- 1-(4-fluoro-3-metho...)
Affinity DataIC50: 3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2021
Entry Details
US Patent