BDBM464176 US10787450, Example 54::tert-butyl 3-(6-methoxy-5-(1H- pyrazol-4-yl)pyridin-2-yl)-1-(3- methoxybenzyl)-2-oxo-1,3,8- triazaspiro[4.5]decane- 8-carboxylate

SMILES COc1cccc(CN2C(=O)N(CC22CCN(CC2)C(=O)OC(C)(C)C)c2ccc(-c3cn[nH]c3)c(OC)n2)c1

InChI Key InChIKey=AUAKSIOEOFTQSK-UHFFFAOYSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 464176   

TargetRho-associated protein kinase 2(Human)
Bristol-Myers Squibb

US Patent
LigandPNGBDBM464176(tert-butyl 3-(6-methoxy-5-(1H- pyrazol-4-yl)pyridi...)
Affinity DataIC50: 3nMAssay Description:The effectiveness of compounds of the present invention as ROCK inhibitors can be determined in a 30 μL assay containing 20 mM HEPES, pH 7.5, 20...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/9/2021
Entry Details
US Patent