BDBM463759 2-[(3R)-1-[5-cyano-6-[(2S)-2-methylazetidin-1-yl]-4-(trifluoromethyl)-2-pyridyl]pyrrolidin-3-yl]acetic Acid::US10781212, Example 1

SMILES C[C@H]1CCN1c1nc(cc(c1C#N)C(F)(F)F)N1CC[C@H](CC(O)=O)C1

InChI Key InChIKey=PFNOWXFRAIHXMZ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 463759   

TargetKetohexokinase(Human)
Eli Lilly

US Patent
LigandPNGBDBM463759(2-[(3R)-1-[5-cyano-6-[(2S)-2-methylazetidin-1-yl]-...)
Affinity DataIC50: 9nMAssay Description:The intrinsic potency of the compounds may be measured using an enzymatic assay which measures the production of F P. Compounds are prepared in DMSO ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
US Patent

TargetIsoform A of Ketohexokinase (Peripheral)(Human)
Eli Lilly

US Patent
LigandPNGBDBM463759(2-[(3R)-1-[5-cyano-6-[(2S)-2-methylazetidin-1-yl]-...)
Affinity DataIC50: 19nMAssay Description:The intrinsic potency of the compounds may be measured using an enzymatic assay which measures the production of F P. Compounds are prepared in DMSO ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
US Patent