BDBM463458 3-(4-Fluorophenyl)-2-(4-(4-methoxyphenyl)piperidin-1-yl)quinoxaline-6-carboxylic acid::US10781185, Example 26::US11459307, Example 26

SMILES COc1ccc(cc1)C1CCN(CC1)c1nc2ccc(cc2nc1-c1ccc(F)cc1)C(O)=O

InChI Key InChIKey=DKHGDKUUKKIFFR-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 463458   

LigandPNGBDBM463458(3-(4-Fluorophenyl)-2-(4-(4-methoxyphenyl)piperidin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Purified hPASK from insect cells (0.02 μg) is added to a 50 μL reaction mix containing 40 mM HEPES (pH 7.0), 100 mM KCl, 5 mM MgCl2, 1 mM D...More data for this Ligand-Target Pair
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Date in BDB:
5/3/2021
Entry Details
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LigandPNGBDBM463458(3-(4-Fluorophenyl)-2-(4-(4-methoxyphenyl)piperidin...)
Affinity DataIC50: 1.00E+3nMAssay Description:Purified PASK (UniProt # Q96RG2; human recombinant N-terminal GST tagged construct, residues 879-1323) from insect cells (final concentration 5 nM) i...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/3/2021
Entry Details
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LigandPNGBDBM463458(3-(4-Fluorophenyl)-2-(4-(4-methoxyphenyl)piperidin...)
Affinity DataIC50: 1.00E+4nMAssay Description:One assay for purified hPASK activity utilizes the Kinase-Glo Luminescent Kinase Assay (Promega), which quantifies the amount of ATP remaining in sol...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2022
Entry Details
Go to US Patent

LigandPNGBDBM463458(3-(4-Fluorophenyl)-2-(4-(4-methoxyphenyl)piperidin...)
Affinity DataIC50: 1.00E+4nMAssay Description:Purified PASK (UniProt #Q96RG2; human recombinant N-terminal GST tagged construct, residues 879-1323) from insect cells (final concentration 5 nM) is...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2022
Entry Details
Go to US Patent