BDBM4631 Anilinoquinazoline deriv. 14::N-(4-chloro-2-fluorophenyl)-6,7-bis(2-methoxyethoxy)quinazolin-4-amine

SMILES COCCOc1cc2ncnc(Nc3ccc(Cl)cc3F)c2cc1OCCOC

InChI Key InChIKey=XTELADPHRDQWCD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4631   

LigandPNGBDBM4631(N-(4-chloro-2-fluorophenyl)-6,7-bis(2-methoxyethox...)
Affinity DataIC50: 60nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
LigandPNGBDBM4631(N-(4-chloro-2-fluorophenyl)-6,7-bis(2-methoxyethox...)
Affinity DataIC50: 900nMpH: 7.4 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Astrazeneca

LigandPNGBDBM4631(N-(4-chloro-2-fluorophenyl)-6,7-bis(2-methoxyethox...)
Affinity DataIC50: 1.00E+5nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed