BDBM4628 Anilinoquinazoline deriv. 11::CHEMBL286160::KDR Kinase Inhibitor, 10::N-(4-Chloro-2-fluorophenyl)-6-methoxy-7-(2-methoxyethoxy)-4-quinazolinylamine hydrochloride::N-(4-chloro-2-fluorophenyl)-6-methoxy-7-(2-methoxyethoxy)quinazolin-4-amine

SMILES COCCOc1cc2ncnc(Nc3ccc(Cl)cc3F)c2cc1OC

InChI Key InChIKey=SWIHGAFGYUTAOY-UHFFFAOYSA-N

Data  9 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 4628   

LigandPNGBDBM4628(KDR Kinase Inhibitor, 10 | N-(4-Chloro-2-fluorophe...)
Affinity DataIC50: 400nMpH: 7.4 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
LigandPNGBDBM4628(KDR Kinase Inhibitor, 10 | N-(4-Chloro-2-fluorophe...)
Affinity DataIC50: 7nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Astrazeneca

LigandPNGBDBM4628(KDR Kinase Inhibitor, 10 | N-(4-Chloro-2-fluorophe...)
Affinity DataIC50: 2.70E+4nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
LigandPNGBDBM4628(KDR Kinase Inhibitor, 10 | N-(4-Chloro-2-fluorophe...)
Affinity DataIC50: 400nMpH: 7.4 T: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
LigandPNGBDBM4628(KDR Kinase Inhibitor, 10 | N-(4-Chloro-2-fluorophe...)
Affinity DataIC50: 7nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
Astrazeneca

LigandPNGBDBM4628(KDR Kinase Inhibitor, 10 | N-(4-Chloro-2-fluorophe...)
Affinity DataIC50: 2.70E+4nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Astrazeneca

LigandPNGBDBM4628(KDR Kinase Inhibitor, 10 | N-(4-Chloro-2-fluorophe...)
Affinity DataIC50: 100nMT: 2°CAssay Description:An ELISA assay was used to determine the ability of inhibitor to inhibit VEGF-R RTK activity. The compounds were incubated with enzyme 20 min at room...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/24/2005
Entry Details Article
PubMed
LigandPNGBDBM4628(KDR Kinase Inhibitor, 10 | N-(4-Chloro-2-fluorophe...)
Affinity DataIC50: 7nMAssay Description:Inhibition assay using KDR.More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/24/2011
Entry Details Article
PubMed
LigandPNGBDBM4628(KDR Kinase Inhibitor, 10 | N-(4-Chloro-2-fluorophe...)
Affinity DataIC50: 7nMAssay Description:Inhibition of KDRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
12/10/2012
Entry Details Article
PubMed