BDBM462252 US10766893, Example 5b::US10766893, Example 6b

SMILES CCOc1nnccc1-c1cc(NCc2cnn(C)c2)c2n(nc(C)c2n1)C(C)CC

InChI Key InChIKey=UXVRWXLBBBUCGV-UHFFFAOYSA-N

Data  6 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 462252   

LigandPNGBDBM462252(US10766893, Example 5b | US10766893, Example 6b)
Affinity DataIC50: 0.360nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent

LigandPNGBDBM462252(US10766893, Example 5b | US10766893, Example 6b)
Affinity DataIC50: 1.90nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent

LigandPNGBDBM462252(US10766893, Example 5b | US10766893, Example 6b)
Affinity DataIC50: 6.10nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent

LigandPNGBDBM462252(US10766893, Example 5b | US10766893, Example 6b)
Affinity DataIC50: 11nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent

LigandPNGBDBM462252(US10766893, Example 5b | US10766893, Example 6b)
Affinity DataIC50: 25nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent

LigandPNGBDBM462252(US10766893, Example 5b | US10766893, Example 6b)
Affinity DataIC50: 102nMAssay Description:PDE1A, PDE1B and PDE1C assays were performed as follows: the assays were performed in 60 μL samples containing a fixed amount of the PDE1 enzyme...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent