BDBM462118 US10766884, Example A35::US10766884, Example A94::US11220494, Example A94

SMILES CC(C)n4c(C(C)(C)O)nc3c(F)cc(c2nc(N[C@@H]1CCOC[C@H]1O)ncc2Cl)cc34

InChI Key InChIKey=QYJLBHRAPDJOSO-UHFFFAOYSA-N

Data  6 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 6 hits for monomerid = 462118   

LigandPNGBDBM462118(US10766884, Example A35 | US10766884, Example A94 ...)
Affinity DataKi:  0.600nMAssay Description:CDK4/Cyclin D1: The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent

LigandPNGBDBM462118(US10766884, Example A35 | US10766884, Example A94 ...)
Affinity DataKi:  0.600nMAssay Description:The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
Go to US Patent

LigandPNGBDBM462118(US10766884, Example A35 | US10766884, Example A94 ...)
Affinity DataKi:  1.5nMAssay Description:CDK4/Cyclin D1: The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent

LigandPNGBDBM462118(US10766884, Example A35 | US10766884, Example A94 ...)
Affinity DataKi:  13.9nMAssay Description:CDK6/Cyclin D3: The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent

LigandPNGBDBM462118(US10766884, Example A35 | US10766884, Example A94 ...)
Affinity DataKi:  13.9nMAssay Description:The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
Go to US Patent

LigandPNGBDBM462118(US10766884, Example A35 | US10766884, Example A94 ...)
Affinity DataKi:  58.9nMAssay Description:CDK6/Cyclin D3: The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent