BDBM462171 (Scheme A-11): Preparation of (3R,4R)-4-({5-chloro-4-[4-fluoro-2-(hydroxymethyl)-1-(2,2,2-trifluoroethyl)-1H-benzimidazol-6-yl]pyrimidin-2-yl}amino)-1-(methanesulfonyl)piperidin-3-ol::US10766884, Example A89::US11220494, Example A89

SMILES Cc1nc2c(F)cc(cc2n1C1COC1)-c1nc(N[C@@H]2CCN(C[C@H]2O)S(C)(=O)=O)ncc1Cl

InChI Key InChIKey=CQHXNOKDYKBAMH-UHFFFAOYSA-N

Data  4 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 462171   

LigandPNGBDBM462171((Scheme A-11): Preparation of (3R,4R)-4-({5-chloro...)
Affinity DataKi:  0.5nMAssay Description:CDK4/Cyclin D1: The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
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LigandPNGBDBM462171((Scheme A-11): Preparation of (3R,4R)-4-({5-chloro...)
Affinity DataKi:  0.5nMAssay Description:The purpose CDK4/Cyclin D1 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitors by us...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
Go to US Patent

LigandPNGBDBM462171((Scheme A-11): Preparation of (3R,4R)-4-({5-chloro...)
Affinity DataKi:  12nMAssay Description:CDK6/Cyclin D3: The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small mo...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
Go to US Patent

LigandPNGBDBM462171((Scheme A-11): Preparation of (3R,4R)-4-({5-chloro...)
Affinity DataKi:  12nMAssay Description:The purpose of the CDK6/Cyclin D3 assay is to evaluate the inhibition (% inhibition, Kiapp and Ki values) in the presence of small molecule inhibitor...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/14/2022
Entry Details
Go to US Patent