BDBM461915 N-(cyclopropanesulfonimidoyl)-5-cyclopropyl-4-((3,5-dichlorophenoxy)methyl)-2-fluorobenzamide::US10766858, Example 3

SMILES NC(=O)c1cc(C2CC2)c(COc2cc(Cl)cc(Cl)c2)cc1F

InChI Key InChIKey=LPMVXKMOKXUMMU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 461915   

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM461915(N-(cyclopropanesulfonimidoyl)-5-cyclopropyl-4-((3,...)
Affinity DataIC50: 3.20nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM461915(N-(cyclopropanesulfonimidoyl)-5-cyclopropyl-4-((3,...)
Affinity DataIC50: 5.76nMAssay Description:isolated from cells that heterologously express hNav1.7 and the β1 subunit Preparation of membranes containing recombinantly expressed sodium ch...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent

TargetSodium channel protein type 9 subunit alpha(Human)
Genentech

US Patent
LigandPNGBDBM461915(N-(cyclopropanesulfonimidoyl)-5-cyclopropyl-4-((3,...)
Affinity DataIC50: 47.8nMAssay Description:The following patch voltage clamp electrophysiology studies were performed on representative compounds of the invention using human embryonic kidney ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/26/2021
Entry Details
US Patent