BDBM4618 1,6-naphthyridine 14::1,6-naphthyridine deriv. 20::3-tert-butyl-1-[3-(3,5-dimethoxyphenyl)-7-{[3-(morpholin-4-yl)propyl]amino}-1,6-naphthyridin-2-yl]urea::N-(tert-Butyl)-N-[3-(3,5-dimethoxyphenyl)-7-[[3-(4-morpholinyl)propyl]amino]-1,6-naphthyridin-2-yl]urea

SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NCCCN3CCOCC3)cc2nc1NC(=O)NC(C)(C)C

InChI Key InChIKey=QNIMLRHYPMIYSE-UHFFFAOYSA-N

Data  7 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 7 hits for monomerid = 4618   

TargetFibroblast growth factor receptor 1(Human)
University of Auckland

LigandPNGBDBM4618(N-(tert-Butyl)-N-[3-(3,5-dimethoxyphenyl)-7-[[3-(4...)
Affinity DataIC50: 31nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2005
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Auckland

LigandPNGBDBM4618(N-(tert-Butyl)-N-[3-(3,5-dimethoxyphenyl)-7-[[3-(4...)
Affinity DataIC50: 4.50E+4nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2005
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Auckland

LigandPNGBDBM4618(N-(tert-Butyl)-N-[3-(3,5-dimethoxyphenyl)-7-[[3-(4...)
Affinity DataIC50: 5.00E+4nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2005
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Mouse)
University of Auckland

LigandPNGBDBM4618(N-(tert-Butyl)-N-[3-(3,5-dimethoxyphenyl)-7-[[3-(4...)
Affinity DataIC50: 4.50E+4nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2005
Entry Details Article
PubMed
TargetFibroblast growth factor receptor 1(Human)
University of Auckland

LigandPNGBDBM4618(N-(tert-Butyl)-N-[3-(3,5-dimethoxyphenyl)-7-[[3-(4...)
Affinity DataIC50: 31nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2005
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Auckland

LigandPNGBDBM4618(N-(tert-Butyl)-N-[3-(3,5-dimethoxyphenyl)-7-[[3-(4...)
Affinity DataIC50: 5.00E+4nMpH: 7.4 T: 2°CAssay Description:Compounds were evaluated for their ability to prevent phosphorylation of a model glutamate-tyrosine copolymer substrate by isolated human FGFR-1, mou...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2005
Entry Details Article
PubMed
TargetVascular endothelial growth factor receptor 2(Human)
University of Auckland

LigandPNGBDBM4618(N-(tert-Butyl)-N-[3-(3,5-dimethoxyphenyl)-7-[[3-(4...)
Affinity DataIC50: 9nMpH: 7.8 T: 2°CAssay Description:Tha assay was using human VEGFR-2 in DELFIA (dissociation-enhanced lanthanide fluoroimmunoassay) format. IC50 is the concentration of inhibitor that ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
10/5/2005
Entry Details Article
PubMed