BDBM4616 1,6-naphthyridine deriv. 18::N-[2-Amino-3-(3,5-dimethoxyphenyl)-1,6-naphthyridin-7-yl]-2,2,2-trifluoroacetamide

SMILES COc1cc(OC)cc(c1)-c1cc2cnc(NC(=O)C(F)(F)F)cc2nc1N

InChI Key InChIKey=PUAOWHQXLKSRPD-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4616   

TargetFibroblast growth factor receptor 1(Human)
University of Auckland

LigandPNGBDBM4616(N-[2-Amino-3-(3,5-dimethoxyphenyl)-1,6-naphthyridi...)
Affinity DataIC50: 61nMpH: 7.4 T: 2°CAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2005
Entry Details Article
PubMed
TargetPlatelet-derived growth factor receptor beta(Human)
University of Auckland

LigandPNGBDBM4616(N-[2-Amino-3-(3,5-dimethoxyphenyl)-1,6-naphthyridi...)
Affinity DataIC50: 5.00E+4nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2005
Entry Details Article
PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Human)
University of Auckland

LigandPNGBDBM4616(N-[2-Amino-3-(3,5-dimethoxyphenyl)-1,6-naphthyridi...)
Affinity DataIC50: 5.00E+4nMAssay Description:IC50 is the inhibitor concentration which inhibits 50% of kinase activity that catalyzes the transfer of the terminal phosphate from [gamma-32P] labe...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/17/2005
Entry Details Article
PubMed