BDBM461421 US10774069, Compound 1::US11072585, Example 120::US11459309, Compound 2::US11793797, Compound 1

SMILES NCc1cc(Oc2cccc(c2)C(=O)N2C[C@@H](O)[C@H](F)C2)nc(c1)C(F)(F)F

InChI Key InChIKey=ODGXXYXJORZPHE-UHFFFAOYSA-N

Data  11 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 461421   

TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM461421(US10774069, Compound 1 | US11072585, Example 120 |...)
Affinity DataIC50: 300nMAssay Description:LOXL2 amine oxidase activity was evaluated by measuring Amplex Red fluorescence using 10-20× concentrated conditioned media (non BSA-containing) from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
Go to US Patent

TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM461421(US10774069, Compound 1 | US11072585, Example 120 |...)
Affinity DataIC50: 300nMAssay Description:LOXL2 amine oxidase activity is evaluated by measuring Amplex Red fluorescence using 10-20× concentrated conditioned media from CHO cells stably expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2022
Entry Details
Go to US Patent

TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM461421(US10774069, Compound 1 | US11072585, Example 120 |...)
Affinity DataIC50: 300nMAssay Description:LOXL2 amine oxidase activity is evaluated by measuring Amplex Red fluorescence using 10-20× concentrated conditioned media from CHO cells stably expr...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/9/2022
Entry Details
Go to US Patent

TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM461421(US10774069, Compound 1 | US11072585, Example 120 |...)
Affinity DataIC50: 300nMAssay Description:LOXL2 amine oxidase activity was evaluated by measuring Amplex Red fluorescence using 10-20× concentrated conditioned media (non BSA-containing) from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2022
Entry Details
Go to US Patent

TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM461421(US10774069, Compound 1 | US11072585, Example 120 |...)
Affinity DataIC50: 300nMAssay Description:LOXL2 amine oxidase activity was evaluated by measuring Amplex Red fluorescence using 10-20× concentrated conditioned media (non BSA-containing) from...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/7/2022
Entry Details
Go to US Patent

TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM461421(US10774069, Compound 1 | US11072585, Example 120 |...)
Affinity DataIC50: 300nMAssay Description:Table 8: LOXL2 amine oxidase activity was evaluated by measuring Amplex Red fluorescence using 10-20× concentrated conditioned media (non BSA-contain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2023
Entry Details
Go to US Patent

TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM461421(US10774069, Compound 1 | US11072585, Example 120 |...)
Affinity DataIC50: 300nMAssay Description:Table 8: LOXL2 amine oxidase activity was evaluated by measuring Amplex Red fluorescence using 10-20× concentrated conditioned media (non BSA-contain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2023
Entry Details
Go to US Patent

TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM461421(US10774069, Compound 1 | US11072585, Example 120 |...)
Affinity DataIC50: 75.1nMAssay Description:Table 9: Human LOX amine oxidase activity was evaluated by measuring Amplex Red fluorescence using 10-20× concentrated conditioned media (BSA-contain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2023
Entry Details
Go to US Patent

TargetLysyl oxidase homolog 2(Human)
Pharmakea

US Patent
LigandPNGBDBM461421(US10774069, Compound 1 | US11072585, Example 120 |...)
Affinity DataIC50: 209nMAssay Description:Table 9: The amine oxidase activity was evaluated by measuring Amplex Red fluorescence using commercially available purified, recombinant human LOXL2...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2023
Entry Details
Go to US Patent

TargetLysyl oxidase homolog 3(Human)
Pharmakea

US Patent
LigandPNGBDBM461421(US10774069, Compound 1 | US11072585, Example 120 |...)
Affinity DataIC50: 1.21E+3nMAssay Description:Table 9: The amine oxidase activity was evaluated by measuring Amplex Red fluorescence using commercially available purified, recombinant human LOXL3...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2023
Entry Details
Go to US Patent

TargetProtein-lysine 6-oxidase (LOX)(Human)
Pharmakea

US Patent
LigandPNGBDBM461421(US10774069, Compound 1 | US11072585, Example 120 |...)
Affinity DataIC50: 4.70E+4nMAssay Description:Table 9: Human LOX amine oxidase activity was evaluated by measuring Amplex Red fluorescence using 10-20× concentrated conditioned media (BSA-contain...More data for this Ligand-Target Pair
In Depth
Date in BDB:
12/5/2023
Entry Details
Go to US Patent