BDBM461267 US10774056, Compound 031::US11542242, Compound 031

SMILES Cc1nc(sc1C(=O)Nc1cc(ccc1N)-c1cccs1)N1CCNCC1

InChI Key InChIKey=ZKJCGFWCOOBGQE-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 461267   

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Regenacy Pharmaceuticals

US Patent
LigandPNGBDBM461267(US10774056, Compound 031 | US11542242, Compound 03...)
Affinity DataIC50: 1.20E+4nMAssay Description:For hERG inhibition assays, the cells used were HEK293 cells stably transfected with hERG (cell line obtained from Cytocentrics Inc. 3463 Magic Drive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
Go to US Patent

TargetCytochrome P450 1A2/2C18/2C19(Human)
Regenacy Pharmaceuticals

US Patent
LigandPNGBDBM461267(US10774056, Compound 031 | US11542242, Compound 03...)
Affinity DataIC50: 1.00E+4nMAssay Description:For Cyp inhibition, human liver microsomes from BD Gentest were incubated with Compound 028 or Compound 032 (10, 3.33, 1.11, 0.37, 0.12, 0.04, 0.01 &...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
Go to US Patent

TargetPotassium voltage-gated channel subfamily H member 2(Human)
Regenacy Pharmaceuticals

US Patent
LigandPNGBDBM461267(US10774056, Compound 031 | US11542242, Compound 03...)
Affinity DataIC50: 1.20E+4nMAssay Description:For hERG inhibition assays, the cells used were HEK293 cells stably transfected with hERG (cell line obtained from Cytocentrics Inc. 3463 Magic Drive...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent

TargetCytochrome P450 1A2(Human)
Regenacy Pharmaceuticals

US Patent
LigandPNGBDBM461267(US10774056, Compound 031 | US11542242, Compound 03...)
Affinity DataIC50: 1.00E+4nMAssay Description:For Cyp inhibition, human liver microsomes from BD Gentest were incubated with Compound 028 or Compound 032 (10, 3.33, 1.11, 0.37, 0.12, 0.04, 0.01 u...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/26/2023
Entry Details
Go to US Patent