BDBM460894 US10774053, Compound 8::US11352329, COMPD # 8

SMILES COc1ccc(c(F)c1)[C@@]1(CC(C)(C)C)NC(=N)N([C@H](COC(=O)N(C)C)c2ccc(Cl)c(c2)-c2ccccn2)C1=O

InChI Key InChIKey=FFQAJSHQPAQCOJ-UHFFFAOYSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 460894   

TargetEnvelope glycoprotein gp160(HIV-1)
Gilead Sciences

US Patent
LigandPNGBDBM460894(US10774053, Compound 8 | US11352329, COMPD # 8)
Affinity DataIC50: 3.60nMAssay Description:Compounds were tested in a high-throughput 384-well assay format for their ability to inhibit the replication of HIV-1 (IIIB) in MT-4 cells. Compound...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
Go to US Patent

TargetEnvelope glycoprotein gp160(HIV-1)
Gilead Sciences

US Patent
LigandPNGBDBM460894(US10774053, Compound 8 | US11352329, COMPD # 8)
Affinity DataEC50:  277nMAssay Description:Assay protocol is identical to that described for the MT-4 antiviral assay with the following changes: Each drug is run in 2 series of quadruplicates...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
Go to US Patent

TargetGag-Pol polyprotein(HIV-1)
Gilead Sciences

US Patent
LigandPNGBDBM460894(US10774053, Compound 8 | US11352329, COMPD # 8)
Affinity DataIC50: 3.60nMAssay Description:Inhibitor potency against HIV protease was measured using an enzymatic assay with a fluorogenic readout. To a reaction buffer containing 100 mM ammon...More data for this Ligand-Target Pair
In Depth
Date in BDB:
9/10/2022
Entry Details
Go to US Patent