BDBM4599 4-anilinoquinazoline deriv. 23::N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-2-(morpholin-4-ylmethyl)prop-2-enamide

SMILES Brc1cccc(Nc2ncnc3ccc(NC(=O)C(=C)CN4CCOCC4)cc23)c1

InChI Key InChIKey=VANCZLKVOHARGS-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 4599   

TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4599(N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-2-(mor...)
Affinity DataIC50: 107nMAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2005
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4599(N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-2-(mor...)
Affinity DataIC50: 458nMAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2005
Entry Details Article
PubMed