BDBM459769 US10774051, Compound I-1232::US11124486, Compound I-1232

SMILES Cc1cc(Nc2nc(=O)c(F)cn2Cc2cc(F)c(F)c(F)c2)c(C)nc1OC(F)F

InChI Key InChIKey=WAXNDZSHGREGND-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 459769   

TargetP2X purinoceptor 7(Human)
Shionogi

US Patent
LigandPNGBDBM459769(US10774051, Compound I-1232 | US11124486, Compound...)
Affinity DataIC50: 6nMAssay Description:Stably expressing cell line (1321N1 cell transfected with the human P2X7 receptor gene (GenBank accession number NM_002562.5 including T606C and G952...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
Go to US Patent

TargetP2X purinoceptor 7(Human)
Shionogi

US Patent
LigandPNGBDBM459769(US10774051, Compound I-1232 | US11124486, Compound...)
Affinity DataIC50: 6nMAssay Description:Stably expressing cell line (1321N1 cell transfected with the human P2X7 receptor gene (GenBank accession number NM_002502.5 including T606C and G952...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
Go to US Patent