BDBM459742 US10774051, Compound I-0697::US10774051, Compound I-0940::US11124486, Compound I-0697

SMILES COc1cn(Cc2cc(F)c(F)c(F)c2)c(Nc2cc3sc(C)nc3cc2C)nc1=O

InChI Key InChIKey=FBQAPUPFOCCPEL-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 459742   

TargetP2X purinoceptor 7(Human)
Shionogi

US Patent
LigandPNGBDBM459742(US10774051, Compound I-0940 | US10774051, Compound...)
Affinity DataIC50: 10nMAssay Description:Stably expressing cell line (1321N1 cell transfected with the human P2X7 receptor gene (GenBank accession number NM_002562.5 including T606C and G952...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Shionogi

US Patent
LigandPNGBDBM459742(US10774051, Compound I-0940 | US10774051, Compound...)
Affinity DataIC50: 10nMAssay Description:Stably expressing cell line (1321N1 cell transfected with the human P2X7 receptor gene (GenBank accession number NM_002502.5 including T606C and G952...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Shionogi

US Patent
LigandPNGBDBM459742(US10774051, Compound I-0940 | US10774051, Compound...)
Affinity DataIC50: 240nMAssay Description:Stably expressing cell line (1321N1 cell transfected with the human P2X7 receptor gene (GenBank accession number NM_002562.5 including T606C and G952...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/25/2021
Entry Details
US Patent

TargetP2X purinoceptor 7(Human)
Shionogi

US Patent
LigandPNGBDBM459742(US10774051, Compound I-0940 | US10774051, Compound...)
Affinity DataIC50: 240nMAssay Description:Stably expressing cell line (1321N1 cell transfected with the human P2X7 receptor gene (GenBank accession number NM_002502.5 including T606C and G952...More data for this Ligand-Target Pair
In Depth
Date in BDB:
2/21/2022
Entry Details
US Patent