BDBM458963 (4-{[2-(4-Bromophenyl)imidazo[,2-a]pyridin-3-yl]methyl}piperazin-1-yl)(cyclopentyl)methanone::US10759794, Example 1

SMILES Brc1ccc(cc1)-c1nc2ccccn2c1CN1CCN(CC1)C(=O)C1CCCC1

InChI Key InChIKey=RWCKYFYFNKRFHA-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 458963   

TargetPotassium channel subfamily K member 3(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM458963((4-{[2-(4-Bromophenyl)imidazo[,2-a]pyridin-3-yl]me...)
Affinity DataIC50: 77nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent

TargetPotassium channel subfamily K member 9(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM458963((4-{[2-(4-Bromophenyl)imidazo[,2-a]pyridin-3-yl]me...)
Affinity DataIC50: 17nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent

TargetPotassium channel subfamily K member 3(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM458963((4-{[2-(4-Bromophenyl)imidazo[,2-a]pyridin-3-yl]me...)
Affinity DataIC50: 7.90nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent

TargetPotassium channel subfamily K member 9(Human)
Bayer Pharma Aktiengesellschaft

US Patent
LigandPNGBDBM458963((4-{[2-(4-Bromophenyl)imidazo[,2-a]pyridin-3-yl]me...)
Affinity DataIC50: 1.04nMAssay Description:The investigations on the inhibition of the recombinant TASK-1 and TASK-3 channels were carried out using stably transfected CHO cells. Here, the com...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent