BDBM458920 US10759793, Example 66

SMILES OCCOc1nc(nc(O[C@@H]2CCCN(C2)C(=O)CC#N)c1F)-c1cnn2ccccc12

InChI Key InChIKey=ZHSRZLKJPPIXFX-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 458920   

TargetTyrosine-protein kinase JAK3 [795-1124](Human)
Almirall

US Patent
LigandPNGBDBM458920(US10759793, Example 66)
Affinity DataIC50: 4nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [826-1132](Human)
Almirall

US Patent
LigandPNGBDBM458920(US10759793, Example 66)
Affinity DataIC50: 0.300nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458920(US10759793, Example 66)
Affinity DataIC50: 10nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent