BDBM458905 US10759793, Example 52

SMILES OCC(=O)N1CCC[C@H](C1)Oc1nc(nc(N2CCOCC2)c1F)-c1cnn2ccccc12

InChI Key InChIKey=HSXKXANEZOHANU-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 458905   

TargetTyrosine-protein kinase JAK3 [795-1124](Human)
Almirall

US Patent
LigandPNGBDBM458905(US10759793, Example 52)
Affinity DataIC50: 11nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [826-1132](Human)
Almirall

US Patent
LigandPNGBDBM458905(US10759793, Example 52)
Affinity DataIC50: 1nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458905(US10759793, Example 52)
Affinity DataIC50: 11nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent