BDBM458868 US10759793, Example 21

SMILES CN([C@@H]1CCCN(C1)C(=O)CC#N)c1nc(nc(-c2ccnc(C)c2)c1F)-c1cnn2ccccc12

InChI Key InChIKey=OJOMLCDNWMYVFZ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 458868   

TargetTyrosine-protein kinase JAK3 [795-1124](Human)
Almirall

US Patent
LigandPNGBDBM458868(US10759793, Example 21)
Affinity DataIC50: 11nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK2 [826-1132](Human)
Almirall

US Patent
LigandPNGBDBM458868(US10759793, Example 21)
Affinity DataIC50: 1nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent

TargetTyrosine-protein kinase JAK1 [850-1154]()
Almirall

US Patent
LigandPNGBDBM458868(US10759793, Example 21)
Affinity DataIC50: 6nMAssay Description:The catalytic domains of human JAK1 (aa 850-1154), JAK2 (aa 826-1132), JAK3 (aa 795-1124) and Tyk2 (aa 871-1187) were expressed as N-terminal GST-fus...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/18/2021
Entry Details
Go to US Patent