BDBM458382 1-(2-(((3R,5S)-1-((6-fluoro-2-methylbenzo[d]thiazol-5-yl)methyl)-5-methylpyrrolidin-3-yl)oxy)-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)ethan-1-one::US10752632, Example 1::US10836773, Example 1

SMILES C[C@H]1C[C@H](CN1Cc1cc2nc(C)sc2cc1F)Oc1ncc2CN(Cc2n1)C(C)=O

InChI Key InChIKey=ACUGCLYHYSHFAE-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 458382   

TargetProtein O-GlcNAcase(Human)
Eli Lilly

US Patent
LigandPNGBDBM458382(1-(2-(((3R,5S)-1-((6-fluoro-2-methylbenzo[d]thiazo...)
Affinity DataIC50: 0.465nMAssay Description:The OGA enzyme catalyses the removal of O-GlcNAc from nucleocytoplasmic proteins. To measure this activity Fluorescein di-N-acetyl-β-N-acetyl-D-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
Go to US Patent

TargetProtein O-GlcNAcase(Human)
Eli Lilly

US Patent
LigandPNGBDBM458382(1-(2-(((3R,5S)-1-((6-fluoro-2-methylbenzo[d]thiazo...)
Affinity DataIC50: 0.465nMAssay Description:The OGA enzyme catalyses the removal of O-GlcNAc from nucleocytoplasmic proteins. To measure this activity Fluorescein di-N-acetyl-β-N-acetyl-D-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
6/30/2021
Entry Details
Go to US Patent

TargetProtein O-GlcNAcase(Human)
Eli Lilly

US Patent
LigandPNGBDBM458382(1-(2-(((3R,5S)-1-((6-fluoro-2-methylbenzo[d]thiazo...)
Affinity DataIC50: 0.465nMAssay Description:Inhibition of full-length human N-terminal poly-His tagged OGA expressed in baculovirus infected Sf9 cells using FD-GlcNAc as substrate preincubated ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/26/2022
Entry Details Article
PubMed