BDBM4581 4-anilinoquinazoline deriv. 10n::CHEMBL93049::N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(methoxymethoxy)but-2-ynamide

SMILES COCOCC#CC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1

InChI Key InChIKey=UCKKZOCKASQMFK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4581   

TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM4581(CHEMBL93049 | N-{4-[(3-bromophenyl)amino]quinazoli...)
Affinity DataIC50: 9nMAssay Description:Inhibition of HER2More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/11/2010
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4581(CHEMBL93049 | N-{4-[(3-bromophenyl)amino]quinazoli...)
Affinity DataIC50: 59nMpH: 7.4 T: 2°CAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2005
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
University of Southern California

Curated by ChEMBL
LigandPNGBDBM4581(CHEMBL93049 | N-{4-[(3-bromophenyl)amino]quinazoli...)
Affinity DataIC50: 122nMAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2005
Entry Details Article
PubMed