BDBM458 3-({2-tert-butyl-4-[(ethylsulfamoyl)amino]-5-methylphenyl}sulfanyl)-4-hydroxy-6-(2-phenylethyl)-6-(propan-2-yl)-5,6-dihydro-2H-pyran-2-one::CHEMBL169074::Dihydropyran-2-one deriv. 63

SMILES CCNS(=O)(=O)Nc1cc(c(SC2C(=O)CC(CCc3ccccc3)(OC2=O)C(C)C)cc1C)C(C)(C)C

InChI Key InChIKey=QZXHJRVMNULICR-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 458   

TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM458(CHEMBL169074 | 3-({2-tert-butyl-4-[(ethylsulfamoyl...)
Affinity DataIC50: 3.30nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2004
Entry Details Article
PubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Parke-Davis Pharmaceutical Research

LigandPNGBDBM458(CHEMBL169074 | 3-({2-tert-butyl-4-[(ethylsulfamoyl...)
Affinity DataIC50: 3.30nMAssay Description:Sensitivity of HIV-1 protease activity to protease inhibitors was determined by a peptide substrate cleavage assay. Protease products were analyzed o...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/6/2004
Entry Details Article
PubMed