BDBM457871 (S)-3-(1-((6-amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyrimidin-4-yl)amino)ethyl)-8-(3-hydroxyprop-1-yn-1-yl)-2-phenylisoquinolin-1 (2H)-one::US10751339, Example 40
SMILES C[C@H](Nc1ncnc(N)c1-c1nc(C)no1)c1cc2cccc(C#CCO)c2c(=O)n1C
InChI Key InChIKey=SNBBYDABBPIQBU-UHFFFAOYSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 457871
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit alpha isoform(Human)
Sunshine Lake Pharma
US Patent
Sunshine Lake Pharma
US Patent
Affinity DataIC50: 704nMAssay Description:PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit beta isoform(Human)
Sunshine Lake Pharma
US Patent
Sunshine Lake Pharma
US Patent
Affinity DataIC50: 154nMAssay Description:PI3K (p110β/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4,5-bisphosphate and MgATP (concentration as ...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3-kinase regulatory subunit alpha/4,5-bisphosphate 3-kinase catalytic subunit delta isoform(Human)
Sunshine Lake Pharma
US Patent
Sunshine Lake Pharma
US Patent
Affinity DataIC50: 5nMAssay Description:PI3K (p110δ/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4, 5-bisphosphate and MgATP (concentration as...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Human)
Sunshine Lake Pharma
US Patent
Sunshine Lake Pharma
US Patent
Affinity DataIC50: 44nMAssay Description:PI3K (p120γ) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4, 5-bisphosphate and MgATP (concentration as required)...More data for this Ligand-Target Pair