BDBM457870 (S)-2-(1-((6-amino-5-(5-methyl-1,3,4-oxadiazol-2-yl)pyrimidin-4-yl)amino)propyl)-5-(3-hydroxyprop-1-yn-1-yl)-3-phenylquinazolin-4(3H)-one::US10751339, Example 37

SMILES CC[C@H](Nc1ncnc(N)c1-c1nnc(C)o1)c1nc2cccc(C#CCO)c2c(=O)n1-c1ccccc1

InChI Key InChIKey=SYZGRLXEOSJVHI-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 457870   

LigandPNGBDBM457870((S)-2-(1-((6-amino-5-(5-methyl-1,3,4-oxadiazol-2-y...)
Affinity DataIC50: 3.00E+3nMAssay Description:PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
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LigandPNGBDBM457870((S)-2-(1-((6-amino-5-(5-methyl-1,3,4-oxadiazol-2-y...)
Affinity DataIC50: 3.00E+3nMAssay Description:PI3K (p110β/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4,5-bisphosphate and MgATP (concentration as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
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LigandPNGBDBM457870((S)-2-(1-((6-amino-5-(5-methyl-1,3,4-oxadiazol-2-y...)
Affinity DataIC50: 45nMAssay Description:PI3K (p110δ/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4, 5-bisphosphate and MgATP (concentration as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
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LigandPNGBDBM457870((S)-2-(1-((6-amino-5-(5-methyl-1,3,4-oxadiazol-2-y...)
Affinity DataIC50: 440nMAssay Description:PI3K (p120γ) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4, 5-bisphosphate and MgATP (concentration as required)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
Go to US Patent