BDBM457855 (S)-3-(1-((6-amino-5-(3-methyl-1,2,4-oxadiazol-5-yl)pyrimidin-4-yl)amino)ethyl)-2-phenyl-8-(prop-1-yn-1-yl)isoquinolin-1(2H)-one::US10751339, Example 16

SMILES CC#Cc1cccc2cc([C@H](C)Nc3ncnc(N)c3-c3nc(C)no3)n(-c3ccccc3)c(=O)c12

InChI Key InChIKey=DWSBFBNKOHQARX-UHFFFAOYSA-N

Data  5 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 457855   

LigandPNGBDBM457855((S)-3-(1-((6-amino-5-(3-methyl-1,2,4-oxadiazol-5-y...)
Affinity DataIC50: 121nMAssay Description:PI3K (p110α/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol 4,5-bisphosphate and MgATP (concentration as ...More data for this Ligand-Target Pair
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Date in BDB:
4/11/2021
Entry Details
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LigandPNGBDBM457855((S)-3-(1-((6-amino-5-(3-methyl-1,2,4-oxadiazol-5-y...)
Affinity DataIC50: 61nMAssay Description:PI3K (p110β/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4,5-bisphosphate and MgATP (concentration as ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
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LigandPNGBDBM457855((S)-3-(1-((6-amino-5-(3-methyl-1,2,4-oxadiazol-5-y...)
Affinity DataIC50: 10nMAssay Description:PI3K (p110δ/p85α) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4, 5-bisphosphate and MgATP (concentration as...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
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LigandPNGBDBM457855((S)-3-(1-((6-amino-5-(3-methyl-1,2,4-oxadiazol-5-y...)
Affinity DataIC50: 26nMAssay Description:PI3K (p120γ) (h) is incubated in assay buffer containing 10 μM phosphatidylinositol-4, 5-bisphosphate and MgATP (concentration as required)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
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TargetPotassium voltage-gated channel subfamily H member 2(Human)
Sunshine Lake Pharma

US Patent
LigandPNGBDBM457855((S)-3-(1-((6-amino-5-(3-methyl-1,2,4-oxadiazol-5-y...)
Affinity DataIC50: 3.00E+4nMAssay Description:Voltage clamp protocol: Computer software was used to set voltage clamp protocols. In whole-cell model, cells were held at −80 mV, first depola...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
Go to US Patent