BDBM457847 6-chloro-1-(1-(1-(4-(trifluoromethyl)phenyl)ethyl)piperidin-4-yl)-1H-benzo[d]imidazol-2(3H) ::US10751335, Example 9

SMILES CC(N1CCC(CC1)n1c2cc(Cl)ccc2[nH]c1=O)c1ccc(cc1)C(F)(F)F

InChI Key InChIKey=GNTLHCRGEZXCRK-UHFFFAOYSA-N

Data  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 457847   

TargetMu-type opioid receptor(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM457847(6-chloro-1-(1-(1-(4-(trifluoromethyl)phenyl)ethyl)...)
Affinity DataEC50:  45nMAssay Description:A standard [35S]GTPγS binding assay in membranes prepared from CHO cells expressing the human MOR was performed in a concentration response mann...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
Go to US Patent

TargetMu-type opioid receptor(Human)
The Scripps Research Institute

US Patent
LigandPNGBDBM457847(6-chloro-1-(1-(1-(4-(trifluoromethyl)phenyl)ethyl)...)
Affinity DataEC50:  35nMAssay Description:he CisBio cAMP cell based assay kit that uses HTRF technology was utilized to assess MOR-mediated inhibition of cAMP. Assays were performed according...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/11/2021
Entry Details
Go to US Patent