BDBM457798 9,9''-((1S,6R,8R,9S,14R,16R,17R,18R)-17,18- difluoro-3,11-dihydroxy-3,11-disulfido- 2,4,7,10,12,15-hexaoxa-3,11- diphosphatricyclo[12.2.1.16,9]octadecane-8,16- diyl)bis(2-amino-1,9-dihydro-6H-purin-6-one) (Diastereomer 1)::US10738074, Example 22::US10738074, Example 23::US10738074, Example 24

SMILES Nc1nc2n(cnc2c(=O)[nH]1)[C@@H]1O[C@@H]2COP(O)(=S)O[C@@H]3[C@H](F)[C@@H](COP(O)(=S)O[C@@H]1[C@@H]2F)O[C@H]3n1cnc2c1nc(N)[nH]c2=O

InChI Key InChIKey=AJDZLPRSJHTUSW-UHFFFAOYSA-N

Data  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 457798   

TargetStimulator of interferon genes protein [H232R](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM457798(US10738074, Example 22 | US10738074, Example 23 | ...)
Affinity DataEC50: <1nMAssay Description:16 nM of [3H] c-GAMP ligand was prepared by diluting into assay buffer, and 50 uL of this working stock was manually added to each well of the assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein [H232R](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM457798(US10738074, Example 22 | US10738074, Example 23 | ...)
Affinity DataEC50:  4nMAssay Description:16 nM of [3H] c-GAMP ligand was prepared by diluting into assay buffer, and 50 uL of this working stock was manually added to each well of the assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
Go to US Patent

TargetStimulator of interferon genes protein [H232R](Human)
Merck Sharp & Dohme

US Patent
LigandPNGBDBM457798(US10738074, Example 22 | US10738074, Example 23 | ...)
Affinity DataEC50:  1.20nMAssay Description:16 nM of [3H] c-GAMP ligand was prepared by diluting into assay buffer, and 50 uL of this working stock was manually added to each well of the assay ...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
Go to US Patent