BDBM457107 US10738053, Example 2.00

SMILES NS(=O)(=O)c1ccc(C(=O)N2C[C@H]3CN(C[C@]3(F)C2)C(=O)OCc2ccc(OC(F)(F)F)cc2)c(F)c1

InChI Key InChIKey=JZWJHPHUGXKWSV-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 457107   

TargetAutotaxin(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM457107(US10738053, Example 2.00)
Affinity DataIC50: 7nMAssay Description:Human ATX: Assay working solutions were made as follows: Assay buffer (50 mM Tris-HCl, 140 mM NaCl, 5 mM KCl, 1 mM CaCl2, 1 mM MgCl2, 0.01% Triton-X-...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
Go to US Patent

TargetCarbonic anhydrase 2(Human)
Hoffmann-La Roche

US Patent
LigandPNGBDBM457107(US10738053, Example 2.00)
Affinity DataIC50: 6nMAssay Description:CA-II: Assay working solutions were made as follows:Assay buffer: 50 mM MOPS, 33 mM Na2SO4, 1 mM EDTA, 0.5 mg/ml BSA, pH 7.5; Enzyme solution: hCA-II...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
Go to US Patent