BDBM457076 Cis-3-[5-(cyclopropylmethyl)- 2-(dimethylamino)-6-oxo-2- phenyl-5,7- diazaspiro[3.4]octan-7- yl]propanenitrile::US10738015, Example SC-45

SMILES CN(C)[C@]1(C[C@@]2(C1)CN(CCC#N)C(=O)N2CC1CC1)c1ccccc1

InChI Key InChIKey=GOMVXLLSQBNAMX-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 457076   

TargetNociceptin receptor(Human)
GrÜNenthal

US Patent
LigandPNGBDBM457076(Cis-3-[5-(cyclopropylmethyl)- 2-(dimethylamino)-6-...)
Affinity DataKi:  25nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
GrÜNenthal

US Patent
LigandPNGBDBM457076(Cis-3-[5-(cyclopropylmethyl)- 2-(dimethylamino)-6-...)
Affinity DataKi:  37nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent