BDBM457068 Cis-7-(6-cyclopropyl-4- methylpyridin-3-yl)-2- (dimethylamino)-5-((3- fluorooxetan-3-yl)methyl)-2- phenyl-5,7- diazaspiro[3.4]octan-6-one::US10738015, Example SC-36

SMILES CN(C)[C@]1(C[C@@]2(C1)CN(C(=O)N2CC1(F)COC1)c1cnc(cc1C)C1CC1)c1ccccc1

InChI Key InChIKey=AZRFOPCYECPXDV-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 457068   

TargetNociceptin receptor(Human)
GrÜNenthal

US Patent
LigandPNGBDBM457068(Cis-7-(6-cyclopropyl-4- methylpyridin-3-yl)-2- (di...)
Affinity DataKi:  10nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
GrÜNenthal

US Patent
LigandPNGBDBM457068(Cis-7-(6-cyclopropyl-4- methylpyridin-3-yl)-2- (di...)
Affinity DataKi:  330nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent