BDBM457062 Cis-2-(dimethylamino)-5-((3- fluorooxetan-3-yl)methyl)-2- phenyl-7-(5- (trifluoromethoxy)pyridin-2- yl)-5,7-diazaspiro[3.4]octan-6- one::US10738015, Example SC-29

SMILES CN(C)[C@]1(C[C@@]2(C1)CN(C(=O)N2CC1(F)COC1)c1ccc(OC(F)(F)F)cn1)c1ccccc1

InChI Key InChIKey=YYHWKUZUWLLARL-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 457062   

TargetNociceptin receptor(Human)
GrÜNenthal

US Patent
LigandPNGBDBM457062(Cis-2-(dimethylamino)-5-((3- fluorooxetan-3-yl)met...)
Affinity DataKi:  16nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
GrÜNenthal

US Patent
LigandPNGBDBM457062(Cis-2-(dimethylamino)-5-((3- fluorooxetan-3-yl)met...)
Affinity DataKi:  65nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent