BDBM457061 Cis-5-(cyclopropylmethyl)-2- (dimethylamino)-2-(3- fluorophenyl)-7-(4-(2- hydroxypropan-2-yl)phenyl)- 5,7-diazaspiro[3.4]octan-6-one::US10738015, Example SC-28

SMILES CN(C)[C@]1(C[C@@]2(C1)CN(C(=O)N2CC1CC1)c1ccc(cc1)C(C)(C)O)c1cccc(F)c1

InChI Key InChIKey=HQBWENCIVSLAJM-UHFFFAOYSA-N

Data  2 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 457061   

TargetNociceptin receptor(Human)
GrÜNenthal

US Patent
LigandPNGBDBM457061(Cis-5-(cyclopropylmethyl)-2- (dimethylamino)-2-(3-...)
Affinity DataKi:  46nMAssay Description:The hNOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl, 10 mM M...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent

TargetMu-type opioid receptor(Human)
GrÜNenthal

US Patent
LigandPNGBDBM457061(Cis-5-(cyclopropylmethyl)-2- (dimethylamino)-2-(3-...)
Affinity DataKi:  78nMAssay Description:The hMOP receptor binding assay was performed as homogeneous SPA-assay (scintillation proximity assay) using the assay buffer 50 mM TRIS-HCl (pH 7.4)...More data for this Ligand-Target Pair
In Depth
Date in BDB:
4/4/2021
Entry Details
US Patent