BDBM4568 4-anilinoquinazoline deriv. 10a::N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dimethylamino)but-2-ynamide

SMILES CN(C)CC#CC(=O)Nc1ccc2ncnc(Nc3cccc(Br)c3)c2c1

InChI Key InChIKey=OTMPOVZNMVTURI-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 4568   

TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4568(N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dim...)
Affinity DataIC50: 6nMpH: 7.4 T: 2°CAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2005
Entry Details Article
PubMed
TargetReceptor tyrosine-protein kinase erbB-2(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4568(N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dim...)
Affinity DataIC50: 14nMAssay Description:The EGF-R kinase autophosphorylation activity was measured by DELFIA/time-resolved fluorometry with excitation at 340 nm and emission at 615 nm. Po...More data for this Ligand-Target Pair
In Depth
Date in BDB:
5/18/2005
Entry Details Article
PubMed
TargetEpidermal growth factor receptor(Human)
Wyeth-Ayerst Research

LigandPNGBDBM4568(N-{4-[(3-bromophenyl)amino]quinazolin-6-yl}-4-(dim...)
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant EGFRMore data for this Ligand-Target Pair
In Depth
Date in BDB:
8/25/2010
Entry Details Article
PubMed