BDBM455813 N-[[(2S)-6-(3-methylbutanoyl)- 6-azaspiro[2.5]octan-2- yl]methyl]-1,3- dihydropyrrolo[3,4-c]pyridine-2- carboxamide::US10730889, Example 413::US11485745, Example 413

SMILES CCCC(=O)N1CCC2(C[C@@H]2CNC(=O)N2Cc3ccncc3C2)CC1

InChI Key InChIKey=FXMZBGGVXMVUBQ-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 455813   

TargetNicotinamide phosphoribosyltransferase(Human)
Forma Tm

US Patent
LigandPNGBDBM455813(N-[[(2S)-6-(3-methylbutanoyl)- 6-azaspiro[2.5]octa...)
Affinity DataIC50: 5.30nMAssay Description:NAMPT Protein Purification. Recombinant His-tagged NAMPT was produced in E. coli cells, purified over a Ni column, and further purified over a size-e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2021
Entry Details
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TargetNicotinamide phosphoribosyltransferase(Human)
Forma Tm

US Patent
LigandPNGBDBM455813(N-[[(2S)-6-(3-methylbutanoyl)- 6-azaspiro[2.5]octa...)
Affinity DataIC50: 5.30nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 17.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
Go to US Patent