BDBM455799 N-[[6-[4- (trifluoromethyl]pyridine-3- carbonyl]-6-azaspiro[2.5]octan- 2-yl]methyl]-1,3- dihydropyrrolo[3,4-c]pyridine-2- carboxamide::US10730889, Example 398::US11485745, Example 398

SMILES FC(F)(F)c1ccncc1C(=O)N1CCC2(CC2CNC(=O)N2Cc3ccncc3C2)CC1

InChI Key InChIKey=MNIDEEVBVHGHCD-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 455799   

TargetNicotinamide phosphoribosyltransferase(Human)
Forma Tm

US Patent
LigandPNGBDBM455799(N-[[6-[4- (trifluoromethyl]pyridine-3- carbonyl]-6...)
Affinity DataIC50: 12.5nMAssay Description:NAMPT Protein Purification. Recombinant His-tagged NAMPT was produced in E. coli cells, purified over a Ni column, and further purified over a size-e...More data for this Ligand-Target Pair
In Depth
Date in BDB:
3/28/2021
Entry Details
Go to US Patent

TargetNicotinamide phosphoribosyltransferase(Human)
Forma Tm

US Patent
LigandPNGBDBM455799(N-[[6-[4- (trifluoromethyl]pyridine-3- carbonyl]-6...)
Affinity DataIC50: 12.5nMAssay Description:The NAMPT enzymatic reactions were carried out in Buffer A (50 mM Hepes pH 17.5, 50 mM NaCl, 5 mM MgCl2, and 1 mM THP) in 96-well V-bottom plates. Th...More data for this Ligand-Target Pair
In Depth
Date in BDB:
1/6/2023
Entry Details
Go to US Patent